JIN Cast Lists
| Role | 2012 (Snow) | 2012 Shinko (Snow) | 2013 (Moon) |
| Minakata Jin (A present-day surgeon) | Otozuki Kei | Ayakaze Sakina | Ryuu Masaki |
| Tachibana Saki (Daughter of a direct retainer to the Shogun)/Yume (Jin's lover) | Maihane Mimi | Toumi Sarasa | Manaki Reika |
| Ogata Koan (Western Doctor) | Asuka Yuu | Yuuto Iriya | Asuka Yuu |
| Shinmon Tatsugoro (Head of the Firefighter group "Wo Kumi") | Natsumi You | Oosumi Rei | Natsumi You |
| Tachibana Ei (Saki's mother) | Rika Masumi | Maisono Ruri | Touka Yurino |
| Sakamoto Ryoma (Former member of the Tosa clan) | Sagiri Seina | Ayanagi Shou | Saou Kurama |
| Katsu Rintaro (Kaishu) (Warship Magistrate of the Tokugawa Shogunate) | Hokushou Kairi | Mana Haruto | Kouzuki Ruu |
| Tachibana Kyotaro (Direct retainer of the Shogun/Saki's older brother) | Misuzu Aki | Kiraha Reo | Miya Rurika |
| Suzuya Taki (Hikosaburo's wife) | Asaki Yumemi | Amane Sara | Saki Akane |
| Matsumoto Ryoujun (Nurse) | Maisaki Rin | Shouno Chio | Akane Konatsu |
| Suzuya Hikosaburo (Master of the red-light district brothel "Suzuya") | Souno Haruto | Asei Itsuki | Ayazuki Seri |
| Yuugiri (Noh actor) | Kaho Anna | Momohana Hina | Tsuzuki Mia |
| Saburi Yusuke (Western doctor) | Saou Kurama | Hokaze Narumi | Uzuki Hayate |
| Senkichi ("Wo Kumi" Firefighter) | Yumeno Seika | Towaki Sea | Tamaki Ryou |
| Jean Le Round (French merchant) | Houshou Dai | Machi Yuuka | Mizuha Kanato |
| Okoma (Young lady of Edo with a pickpocketing business) | Daigo Seshiru | Hoshino Anri | Moeka Yuria |
| Nakaoka Shintaro (Ryouma's sworn friend) | Renjou Makoto | Tsukishiro Kanato | Mishou Kazuki |
| Kondo Isami (Head of the Shinseigumi) | Karyou Shizuru | Ou Ibuki | Arise Sou |
| Nokaze (Call Courtesan) | Manaka Ayu | Yumeka Ami | Hanahi Mira |
| Mystery ER patient/Shinnosuke ("Wo Kumi" Firefighter) | Touma Kazuki | - | Hoshina Yutaka |
| Oharu (Daughter of a samurai) | Shiranagi Suzu | Sara Anna | Misato Yumeno |
| Miki Hanbei (Assassin) | Ouga Mitsuki | - | Kirami Ruise |
| Akane (Poster girl for a Japanese-style confectionary shop) | Toumi Sarasa | Himehana Yukino | Harune Aki |
| Yamada Jun'an (Former Western Medical School doctor) | Ayanagi Shou | Ouji Kaoru | Chinami Karan |
| Yamamoto Seijuurou (Assassin) | Mana Haruto | - | Shouga Tsubaki |
| Kaede (Ninja) | Shouno Chio | Hanae Chiho | Samomo Satsuki |
| Takaoka Gensai (Assassin for the Kyoto Mimawarigumi) | Ayakaze Sakina | Kujou Asu | Houzuki An |
| Sawamura Tanosuke (Kabuki actor) | Hokaze Narumi | Tachibana Kou | Takasumi Hayato |
| Choushichirou (Book Vendor) | Kujou Asu | Amatsuki Tsubasa | Hibiki Reona |
| Onatsu (Daughter of a samurai) | Ai Sumire | - | Urara Senri |
| Kiichi (Boy that sells soybeans and boiled eggs) | Hoshino Anri | Karen Emiri | Kousaki Ran |
| Daigorou (Okoma's younger brother) | Sara Anna | - | Akane Konatsu |